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Old 07-02-2012, 03:54 PM   #1
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Ever wonder how painkillers work?



Some people take aspirin or ibuprofen to treat everyday aches and pains, but how exactly do the different classes of pain relievers work? Learn about the basic physiology of how humans experience pain, and the mechanics of the medicines we've invented to block or circumvent that discomfort.

Lesson by George Zaidan, animated by Augenblick Studios.

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Old 07-02-2012, 04:40 PM   #2
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It's scary to think of the amount of damage these painkillers are doing; Ibuprofen and Paracetamol should have been banned already, but instead they try to ban Vitamin C

1) Ibuprofen - Heart Attacks, Strokes, kills people with Chicken Pox

2) Paracetamol - Destroying livers, sometimes even when well within 'safe' dosage

3) Aspirin - Bleeding in the stomach, also kills people with Chicken Pox

Not to mention that the pain is there to protect us, to tell us that we are damaging our back if we move into a certain position, this stops us making it worse.

If somebody is already terminally ill, beyond repair, then painkillers are a blessing
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Old 07-02-2012, 04:52 PM   #3
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So what do you recommend for pain relief, whp?
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Old 07-02-2012, 04:55 PM   #4
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Quote:
Originally Posted by wehateporn View Post
It's scary to think of the amount of damage these painkillers are doing; Ibuprofen and Paracetamol should have been banned already, but instead they try to ban Vitamin C

1) Ibuprofen - Heart Attacks, Strokes, kills people with Chicken Pox

2) Paracetamol - Destroying livers, sometimes even when well within 'safe' dosage

3) Aspirin - Bleeding in the stomach, also kills people with Chicken Pox

Not to mention that the pain is there to protect us, to tell us that we are damaging our back if we move into a certain position, this stops us making it worse.

If somebody is already terminally ill, beyond repair, then painkillers are a blessing
Now you are stepping on my territory - I will take your crap 'Illuminati' videos and give them a second look.

Don't fuck with peoples health though.
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Old 07-02-2012, 05:01 PM   #5
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So what do you recommend for pain relief, whp?
Running is superb, though not always possible. Depends what it is you've got. For toothache running works well, for back problems it's different, if you have back problems and take painkillers, make sure that you don't do anything while you're on them. I have an aunt who takes painkillers for her back pain before she cleans the house, this means she's doing herself a lot more damage preventing her back from getting recovering, leaving her dependent on the painkillers as she progressively increases the damage to her back.

Here's are the natural and safe painkillers recommended by Dr Mercola:-

Ginger: This herb is anti-inflammatory and offers pain relief and stomach-settling properties. Fresh ginger works well steeped in boiling water as a tea or grated into vegetable juice.

Boswellia: Also known as boswellin or "Indian frankincense," this herb contains specific active anti-inflammatory ingredients.

Fish Oils: The omega-3 fats EPA and DHA contained in fish oil have been found, by many animal and clinical studies, to have anti-inflammatory properties.

Bromelain: This enzyme found in pineapples, is a natural anti-inflammatory. It can be taken in supplement form but eating fresh pineapple may also be helpful.

Cetyl Myristoleate (CMO): This oil, found in fish and dairy butter, acts as a "joint lubricant" and an anti-inflammatory.

Evening Primrose, Black Currant and Borage Oils: These contain the essential fatty acid gamma linolenic acid (GLA), which is useful for treating arthritic pain.

Cayenne Cream: Also called capsaicin cream, this spice comes from dried hot peppers. It alleviates pain by depleting the body's supply of substance P, a chemical component of nerve cells that transmits pain signals to your brain.
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Old 07-02-2012, 05:02 PM   #6
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Don't fuck with peoples health though.
Pain is there to protect health, so yes I'm with you on not messing with people's health, which is what the painkillers do
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Old 07-02-2012, 05:04 PM   #7
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As I thought, pass. You can stop giving medical advice now.
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Old 07-02-2012, 05:10 PM   #8
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As I thought, pass. You can stop giving medical advice now.
Common painkillers are harming and killing a lot of people, if you're going to take them make sure it's for a damn good reason. If you can avoid them, do!


Paracetamol warning: 'Slightly too much can cause overdose'

http://www.bbc.co.uk/news/health-15837468

"Taking slightly too much paracetamol day after day can be fatal, experts have warned."

Ibuprofen 'trebles the risk of a stroke' as doctors warn over dangers of long-term use
http://www.dailymail.co.uk/health/ar...#ixzz1zVtcm8VH

"Large regular doses of ibuprofen and similar painkillers could treble the risk of strokes and increase the likelihood of heart attacks, researchers are warning."

Major bleeding with aspirin in primary prevention underestimated
http://www.theheart.org/article/1410099.do

"Published in the June 6, 2012 issue of the Journal of the American Medical Association, the study showed that aspirin was associated with a 55% relative increase in the risk of major bleeding, a number that translates to two excess bleeding events for every 1000 patients treated annually."
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Old 07-02-2012, 05:22 PM   #9
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Originally Posted by wehateporn View Post
Common painkillers are harming and killing a lot of people, if you're going to take them make sure it's for a damn good reason. If you can avoid them, do!


Paracetamol warning: 'Slightly too much can cause overdose'

http://www.bbc.co.uk/news/health-15837468

"Taking slightly too much paracetamol day after day can be fatal, experts have warned."

Ibuprofen 'trebles the risk of a stroke' as doctors warn over dangers of long-term use
http://www.dailymail.co.uk/health/ar...#ixzz1zVtcm8VH

"Large regular doses of ibuprofen and similar painkillers could treble the risk of strokes and increase the likelihood of heart attacks, researchers are warning."

Major bleeding with aspirin in primary prevention underestimated
http://www.theheart.org/article/1410099.do

"Published in the June 6, 2012 issue of the Journal of the American Medical Association, the study showed that aspirin was associated with a 55% relative increase in the risk of major bleeding, a number that translates to two excess bleeding events for every 1000 patients treated annually."
Paracetamol is safe if you don't take an overdose. No shock there.....

Aspirin saves millions of lives every year - You missed that fact.

If you have gastric problems don't take NSAIDS - Also simple.
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Old 07-02-2012, 05:22 PM   #10
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Originally Posted by wehateporn View Post
It's scary to think of the amount of damage these painkillers are doing; Ibuprofen and Paracetamol should have been banned already, but instead they try to ban Vitamin C

1) Ibuprofen - Heart Attacks, Strokes, kills people with Chicken Pox

2) Paracetamol - Destroying livers, sometimes even when well within 'safe' dosage

3) Aspirin - Bleeding in the stomach, also kills people with Chicken Pox

Not to mention that the pain is there to protect us, to tell us that we are damaging our back if we move into a certain position, this stops us making it worse.

If somebody is already terminally ill, beyond repair, then painkillers are a blessing
Banned - no. Regulated better - yes.

My wife suffers from reumatoid arthritis to the point where she receives regular cortisone injections (after joint draining), methotrexate injections and plaquinil infusion treatments...and still endures an unbelievable amount of pain on a daily basis. The cost of the infusion treatments is phenomenal - $2k per session (thankfully we have great benefit coverage).

Even with all that - on a good day, she has to dose up on Aleve just to be semi-mobile. As a child her doctor had her on a regiment of up to 20-30 aspirin a day (which to this day she thinks did more harm than good at the time).
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Old 07-02-2012, 05:38 PM   #11
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So what do you recommend for pain relief, whp?
Heroin or Oxycodone (Oxycontin). Heroin is actually one of the least harmful drugs you can do, even less harmful than tylenol or caffeine. It's only dangerous in the way people do it, e.g. unmeasured street doses, dirty needles, etc.
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Old 07-02-2012, 05:40 PM   #12
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Paracetamol is safe if you don't take an overdose. No shock there.....
Destruction of one's liver for a slight overdose seems like far too big a risk, especially when it's just for a hangover. You don't necessarily even need to overdose if you've got Alcohol in your blood, in which case the maximum daily intake needs to be halved. Not many people know that, but they should given that it could take their liver out. Coffee also elevates the levels of paracetamol-induced liver toxins, so brings down the maximum safe daily dosage. http://howto.yellow.co.nz/health-nut...u-should-know/

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Aspirin saves millions of lives every year - You missed that fact.
Problem is that it's doing more harm than good overall. You would have to be very careful as to which category of people were given Aspirin for the positive to outweigh the negative

"The study of 100,000 healthy people who have taken aspirin, the largest of its kind, found that the drug reduced the risk of heart attacks by about 10 per cent. The risk of "non-trivial" bleeding rose by a third."

http://www.smh.com.au/national/healt...110-1psre.html
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Old 07-02-2012, 05:41 PM   #13
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Banned - no. Regulated better - yes.

My wife suffers from reumatoid arthritis to the point where she receives regular cortisone injections (after joint draining), methotrexate injections and plaquinil infusion treatments...and still endures an unbelievable amount of pain on a daily basis. The cost of the infusion treatments is phenomenal - $2k per session (thankfully we have great benefit coverage).

Even with all that - on a good day, she has to dose up on Aleve just to be semi-mobile. As a child her doctor had her on a regiment of up to 20-30 aspirin a day (which to this day she thinks did more harm than good at the time).
Agreed SilentKnight

That's a lot of Aspinin's she was given
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Old 07-02-2012, 05:43 PM   #14
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Originally Posted by wehateporn View Post
Running is superb, though not always possible. Depends what it is you've got. For toothache running works well, for back problems it's different, if you have back problems and take painkillers, make sure that you don't do anything while you're on them. I have an aunt who takes painkillers for her back pain before she cleans the house, this means she's doing herself a lot more damage preventing her back from getting recovering, leaving her dependent on the painkillers as she progressively increases the damage to her back.

Here's are the natural and safe painkillers recommended by Dr Mercola:-

Ginger: This herb is anti-inflammatory and offers pain relief and stomach-settling properties. Fresh ginger works well steeped in boiling water as a tea or grated into vegetable juice.

Boswellia: Also known as boswellin or "Indian frankincense," this herb contains specific active anti-inflammatory ingredients.

Fish Oils: The omega-3 fats EPA and DHA contained in fish oil have been found, by many animal and clinical studies, to have anti-inflammatory properties.

Bromelain: This enzyme found in pineapples, is a natural anti-inflammatory. It can be taken in supplement form but eating fresh pineapple may also be helpful.

Cetyl Myristoleate (CMO): This oil, found in fish and dairy butter, acts as a "joint lubricant" and an anti-inflammatory.

Evening Primrose, Black Currant and Borage Oils: These contain the essential fatty acid gamma linolenic acid (GLA), which is useful for treating arthritic pain.

Cayenne Cream: Also called capsaicin cream, this spice comes from dried hot peppers. It alleviates pain by depleting the body's supply of substance P, a chemical component of nerve cells that transmits pain signals to your brain.
You forgot opium and marijuana plants.
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Old 07-02-2012, 05:44 PM   #15
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Heroin or Oxycodone (Oxycontin). Heroin is actually one of the least harmful drugs you can do, even less harmful than tylenol or caffeine. It's only dangerous in the way people do it, e.g. unmeasured street doses, dirty needles, etc.
It's amazing what one discovers when researching Heroin
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Old 07-02-2012, 05:45 PM   #16
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You forgot opium and marijuana plants.
Good additions epitome!
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Old 07-02-2012, 05:47 PM   #17
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I just used garlic as an antiseptic, righteo man, righteo.
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Old 07-02-2012, 05:49 PM   #18
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I just used garlic as an antiseptic, righteo man, righteo.
Garlic has Power!
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Old 07-02-2012, 06:35 PM   #19
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interesting thread, i am on Oxicodone and Ibuprofen right now.
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Old 07-02-2012, 06:39 PM   #20
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A little known fact about John Hopkins... he did a lot of opium. A LOT.

I guess the lesson is do opium and open one of the world's most prestigious hospital.

I kid, I kid...
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Old 07-02-2012, 06:41 PM   #21
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Garlic has Power!
It immediately burned my hands like no other but that was merrily the microbes attempting to burrow deeper into my skin before dying. I eat garlic daily. It removes arterial plaque like a mother. Must eat it with bananas and nuts though. Garlic 101
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Old 07-02-2012, 07:07 PM   #22
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I take Norco (hydrocodone) when needed for pain my neurosurgeon told me its WAY safer than Ibuprofen and would even be safer without the tylenol in it but the tylenol is mandated by the FDA to (GET THIS) discourage recreational use...ie we dont want you to use it recreationally so we will make it kill you if you do.....(the Tylenol/acetaminaphin/paramecetol) is what kills users over time.

Norco is hydrocodone with a low cut of tylenol (325mg instead of 500)
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Old 07-02-2012, 07:13 PM   #23
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Not a business thread, but I'll okay this thread because its very informative.


Good jobs guys.
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Old 07-02-2012, 07:14 PM   #24
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ive suffered of tooth ache my entre life, i have a very sensitive mouth and i have to go to the dentist every 3 months... anyway marijuana has helped a lot to deal with pain.. i take medicines when its extremely urgent, but theres people who take pills for any dumb thing, making the body a very dependant form of living
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Old 07-02-2012, 07:24 PM   #25
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I got a pretty good idea.
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Old 07-02-2012, 07:58 PM   #26
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Heroin or Oxycodone (Oxycontin). Heroin is actually one of the least harmful drugs you can do, even less harmful than tylenol or caffeine. It's only dangerous in the way people do it, e.g. unmeasured street doses, dirty needles, etc.
That's actually true -- if the use is short term only. Dilaudid-HP for intravenous (IV) works wonders for a few hours

Most of the OTC drugs the OP Poster referred to are NSAIDs with the exception of Tylonol and its generic forms.

If you use them occasionally for a headache no big deal.

You can brass out most minor headaches anyway ...

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Old 07-02-2012, 08:04 PM   #27
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I take Norco (hydrocodone) when needed for pain my neurosurgeon told me its WAY safer than Ibuprofen and would even be safer without the tylenol in it but the tylenol is mandated by the FDA to (GET THIS) discourage recreational use...ie we dont want you to use it recreationally so we will make it kill you if you do.....(the Tylenol/acetaminaphin/paramecetol) is what kills users over time.

Norco is hydrocodone with a low cut of tylenol (325mg instead of 500)
They don't HAVE to, but that is why it is usually prescribed APAP. They make oxycodone without the aspirin its just doctors hate prescribing it without good reason.
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Old 07-02-2012, 10:58 PM   #28
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So what do you recommend for pain relief, whp?
An all natural substance..

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Old 07-03-2012, 12:37 AM   #29
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They don't HAVE to, but that is why it is usually prescribed APAP. They make oxycodone without the aspirin its just doctors hate prescribing it without good reason.
Thats because in its pure form its (oxycodone) a sched 2 instead of a sched 3 meaning the feds will scrutinize the scrip MUCH more carefully

and yes it is, as of now a requirement that hydrocodone be combined with either aspirin, ibuprofen or acetaminophen although newer class 2 variations are being developed and will require FDA approval.
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Old 07-03-2012, 12:50 AM   #30
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Thats because in its pure form its (oxycodone) a sched 2 instead of a sched 3 meaning the feds will scrutinize the scrip MUCH more carefully

and yes it is, as of now a requirement that hydrocodone be combined with either aspirin, ibuprofen or acetaminophen although newer class 2 variations are being developed and will require FDA approval.
Oxycontin, Roxicodone = pure oxycodone

hydrocodone = oxycodone mixed with aspririn, acetaminophen
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Old 07-03-2012, 01:28 AM   #31
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I used to have a bad Heroin habit, was never using it for pain but I had a few buddies that had legitimate pain problems and they would tell me Heroin was more effective then their prescription pain medications. Whomever posted about it being one of the least harmful drugs is right, most problems do stem from people not using clean/new syringes and not gauging their doses/or combining it with other drugs.

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Old 07-03-2012, 01:45 AM   #32
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Thats because in its pure form its (oxycodone) a sched 2 instead of a sched 3 meaning the feds will scrutinize the scrip MUCH more carefully

and yes it is, as of now a requirement that hydrocodone be combined with either aspirin, ibuprofen or acetaminophen although newer class 2 variations are being developed and will require FDA approval.
Here is a list from the DEA of all scheduled drugs. There is no distinction between with acetaminophen and without. Oxycodone (including percocet, which includes acetaminophen) are schedule II.

The FDA has actually called for manufacturers to limit the amount of acetaminophen to no more than 325/mg per pill.

They have not banned pure oxycodone and cannot for a variety of reasons. They're concerned about too much acetaminophen.
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Old 07-03-2012, 01:53 AM   #33
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I take Norco (hydrocodone) when needed for pain my neurosurgeon told me its WAY safer than Ibuprofen and would even be safer without the tylenol in it but the tylenol is mandated by the FDA to (GET THIS) discourage recreational use...ie we dont want you to use it recreationally so we will make it kill you if you do.....(the Tylenol/acetaminaphin/paramecetol) is what kills users over time.

Norco is hydrocodone with a low cut of tylenol (325mg instead of 500)
They put APAP with hydrocodone because the APAP potentiates the hydrocodone.

Last edited by anexsia; 07-03-2012 at 02:01 AM..
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Old 07-03-2012, 02:49 AM   #34
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I used to have a bad Heroin habit, was never using it for pain but I had a few buddies that had legitimate pain problems and they would tell me Heroin was more effective then their prescription pain medications. Whomever posted about it being one of the least harmful drugs is right, most problems do stem from people not using clean/new syringes and not gauging their doses/or combining it with other drugs.
Heroin has some different alkaloids in it that give people a more euphoric feeling than synthetic opiods; however, most of them break down into morphine once they're in your body. They're all basically the same drug with varying degrees of strength. Except for fentanyl and methadone. Maybe a couple others.

Benzos and heroin are a deadly combo. Had a couple friends die from that. A little while ago near me there was a batch of heroin going around that was mostly fentanyl, which is way stronger than heroin. People were dying left and right off of that shit. The cops cracked down real hard on that neighborhood when all these white suburban kid's dead bodies started popping up all over alleyways and abandoned houses there.
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Old 07-03-2012, 03:06 AM   #35
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Paracetamol is very dangerous , so use it in small doses and only when necessary
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Old 07-03-2012, 03:22 AM   #36
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roxicodone > *

it's instant release oxycodone and doesn't contain anything other than binders like microcrystalline cellulose.

plus it doesn't make you feel like junk after you come down off of it like heroin does.
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Old 07-03-2012, 03:54 AM   #37
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People use Kratom for headache, back pain and all kind of pains. It does also decreases anxiety. (works on the opioid receptors)
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Old 07-03-2012, 06:10 AM   #38
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Banned - no. Regulated better - yes.

My wife suffers from reumatoid arthritis to the point where she receives regular cortisone injections (after joint draining), methotrexate injections and plaquinil infusion treatments...and still endures an unbelievable amount of pain on a daily basis. The cost of the infusion treatments is phenomenal - $2k per session (thankfully we have great benefit coverage).

Even with all that - on a good day, she has to dose up on Aleve just to be semi-mobile. As a child her doctor had her on a regiment of up to 20-30 aspirin a day (which to this day she thinks did more harm than good at the time).
ginger is supposed to help to reduce pain significantly. May be a natural way to help with this. Hope it helps some anyway.

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Old 07-03-2012, 06:27 AM   #39
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You forgot opium and marijuana plants.
I'm thankful to live in a region of the world where they still have fields and fields full of poppy plants. The locals always sell raw opium dirty cheap. The best pain reliever their is.
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Old 07-03-2012, 06:29 AM   #40
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aspirin is quite natural - originating from willow bark. even animals chew on that when they have pain.

just take one if you need one - dont take them daily
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