Monetizing Big Boobs Podcast

Record the podcast on video and audio. Hook up deals with companies directly.

What's it about? Big boobs? What about them :D.

Boobsrealm.com but in audio. People in the big boobs community like the rumors and know about the models or get to know new models.
ALso interviews with producers and models and guest fans.

Seems to be the best route. Monetizing the audio + visual audience.
Truthfully I watch podcasts more than I listen.

Could also edit a clip show that goes with the cast.

You should be able to upload it to Soundcloud, Spotify, iTunes/Apple Music and monetize views or streams that way.

This is your answer right here, you need to approach companies directly and work out pay for performance deals with them. My buddy has a fairly successful comedy podcast, and in the early days before he had an audience nobody would pay to advertise with him unless he passed a certain downloads per episode threshold. Back then I would hear Adam & Eve advertising on a lot of podcasts, so I approached them and they hooked him up with a code that he advertised on the podcasts, and he would get paid on a percentage of sales deal. A few of the larger pharmacy websites gave him the same deal. It wasn't huge money, but as he grew it was a couple bucks to make doing the podcast worthwhile. Later on when he grew his numbers companies would start hitting him up to advertise, and now he has Blue Chew and a few others on a more traditional advertising deal...

Given your target audience is primarily interested in audio, you should monetize your podcast with a vanity phone sex number like 800-Big-Tits, 888-Titties, 877-Boobies, 866-Breasts, 855-Nipples or 844-Fun-Bags.