I've been happy with Symantec's "Endpoint" corporate protection package. Probably not the cheapest; but, I am always pleasantly surprised at what it stops.
I have kaspersky for virus protection and I still use malwarebytes. Of course I only use the free version. The one thing I have noticed is if I did get a few mals is that if I run it a second time then it usually picks up a hanger. So I always run it twice.
If you are just using a PC go with Microsoft's security essentials. It's completely free and for reviews it does fairly well in comparison to the other major vendors.
If you are fiddling around all day on questionable sites go with a better vendor, otherwise microsofts own product has done very well.
Also, if you are just browsing different sites just use a linux box, or a live linux on a usb drive.
Power off, garbage gone.
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