Is there a trading script that cando this.....
 

I'm looking for a script that allows you to specify groups(niches) for each trade site and trade accordingly.

Is there a script that could do this and handle say...40 groups or so?

I'm pretty sure you can do that with any decent script. X3, TM3, UCJ, etc. I'm sure they all have groups, I know for sure TM3 does.