Guitar Hero 3 is fun, BUT....
 

Goddamn, I had to ice my wrist this morning after playing for the very first time on my PS3.

I'd have to advise not playing for 4 hours straight the first session out of the box, unless you like not being able to perform simple dexterity tasks for a day or two.

That's how I was when I picked up Guitar Hero 2 last year. My left hand was pretty well useless for about a month or so.

In my case, it's my strumming hand(right). The button pressin digits are fine. I play real guitar also, and my hands never hurt this bad.

my wrist killed me after playing for a while to. i have it for xbox 360,but do you know if you can play the 80's rock one for the PS2 on the PS3?

From what I've read, no.