can gfy raise $1m?
 

most people talk crap about how much money they make. so here is a good cause

The purpose of Reach for the Cure Foundation is to raise funds for the groundbreaking work of Dr. Denise Faustman, MD, PhD at Massachusetts General Hospital (MGH). Reach for the Cure is working with MGH to raise money to support Dr. Faustman's clinical trials. We have set a goal of $1 million. Our $1 million will be part of the $11 million MGH is raising to support the human clinical trials at MGH in pursuit of a cure for type 1 diabetes. We are turning to you. Together we can meet this challenge. Let's make it happen, and Reach for the Cure!

For 20 years, diabetics have been told that a cure is "just around the corner." Now that dream is within our reach. We have looked at every kind of research to help our daughter fight this devastating disease, and Dr. Faustman has finally given us real hope for a cure!
The greatest obstacle to Dr. Faustman's research is the lack of funds. It will take $11 million to proceed with the human clinical trials.

Dr. Faustman is the only person to cure this deadly disease in mice and needs the funds to test it on humans.

25% of americans have this disease, 80% of them children and its growing. it will eventually kill 65% of them.

http://www.reachforthecure.org/index.php

:helpme

what about aids and ms?

they are good causes too, but the fact is this doctor HAS found a cure and cant get funding to test it because its a cheap fix that pharmaceutical companys wont make money from. and they badly need help.

If any industry can raise $1m it is this one.

Think of what's going on here for a minute.

Just let it all sink in for a minute.......


This industry is under attack by the right wing & christain right...

Now, what if this industry raised the $1m & it was public.

$1m+ raised for lukemia cure by porn!! think about the possibility of this having an effect on how people view this biz.

But what is more important is that people in this biz are capable of donating large sums. People in this biz are also capable of making things happen fast & getting the word out. And even more important, A CURE!!!!!

Good cause. Diabetes is growing very quickly in Western countries.

No doubt of that.


The problem here is... If the stats above are correct, (and got no reason to doubt them), why are the pharma corps not funding Faustman's research? $11m is little in research terms.

If it is in keeping with the track record, - it's down to a bottom line dollar again. We have a market of 25% (?) of the US population, plus markets in other countries and drug corps are not interested in funding research????

Rest assured they will come up with their version and this will require sustained medication monthly at a cost to users resulting in daily revenues to pharam corps which will exceed that $11 million research cost.

Think on it.

PS Drug companies are not interested in cures - they are interested in medications.

this was answered

pharma companys make 1.3 billion per year in the us from insulin alone.
insulin may keep you alive but it still has very serious complications, like losing toes, feet, legs, kidneys, heart attacks, blindness etc.

this dr has found a cure but not many are interested in helping her.
chrysler has donated $1m to kick it off.

im kicking in $15,000

I'd highly doubt we could do that for a single cause...

bingo..........

The search for a cure to diabetes has been a focused effort by hundreds of scientists for nearly thirty years. Basic scientific discovery has contributed to many significant advancements in this quest. Many improvements in diabetes care have emerged, and much human suffering has been spared. But no previous research has achieved the cure of a fully insulin dependent diabetic mouse, recently attained by a group of scientists at MGH - a discovery that holds the hope that a cure for this terrible disease can be found.


In a major breakthrough, published in the Journal of Clinical Investigation in July 2001, Dr. Faustman and her colleagues at MGH have cured diabetic (NOD) mice, for the first time ever. That is, they have devised a treatment which restored normal blood glucose levels permanently. This was achieved with a 40-day treatment program, which is entirely different from any previously attempted, was based on previous discoveries in Dr. Faustman's laboratory on the nature of the autoimmune response.


In her previous work, Dr. Faustman has identified a singular immune T cell defect in diabetic mice that is responsible for the destruction of insulin producing beta cells. This T cell defect is due to a genetically identifiable trait, and it is because of this defect that the cells can be mature inappropriately to attack the beta cells and become autoreactive T cells. Luckily, this same defect also results in a flaw that allows these T cells to be singled out and destroyed. That is, the cells are more susceptible to the effects of a signaling protein, known as TNF-alpha, which initiates the process of apoptosis, or cell suicide. A second part of the treatment prevents the redevelopment of the disease producing autoimmune T cells. Immune cells from another tissue-matched individual are able to re-educate the T-cells to recognize the pancreatic beta cells as "self", effectively re-educating the immune system, and preventing autoimmune cell formation and beta cell destruction. The natural process of beta cell regeneration then cured the diabetes in the mouse experiments. This process of destroying the defective T cells and preventing their recurrence is described as immunomodulation.



The MGH research team has considerable evidence that this T cell defect found in diabetic mice is physiologically identical to that found in diabetic humans. Defective T cells were in all of the 100 Type 1 diabetic patients that have been screened to date and none of the healthy control subjects. Furthermore, the severity of the T cell defect seems to be directly proportional to the age of diabetes onset. The younger the patient, the greater degree of T cell defect.


The next step in this research is to develop a laboratory assay for rapid and accurate analysis of defective cells in patient blood samples, suitable for use in a clinical study. This assay will enable physicians to identify patients who are likely to benefit from the treatment and can also be used to provide evidence of the success of the treatment. This step will be accomplished through the collaboration of Dr. Faustman with Dr. David Nathan, an internationally recognized clinician and clinical investigator in the field of diabetes.


In a second major breakthrough, another team of MGH researchers led by Dr. Joel Habener, announced their exciting discovery of stem cells within the pancreatic islets in March 2001. This discovery is of vital importance for the cure of long term Type 1 diabetes (when the natural supply of pancreatic stem cells may have died out) and is also likely to benefit those with Type 2 diabetes. Stem cells are immature cells that can proliferate indefinitely and provide a source of cells that can mature into many cell types, including beta cells, a normal process that replaces cells that have naturally died out. Other research suggests that these stem cells may survive in the pancreas for some years after the onset of frank insulin dependency, still maturing into beta cells only to be immediately destroyed by autoreactive T cells.


Thus, if the autoimmunity is eliminated, as in the mice experiments, the patients may cure themselves with the residual beta stem cells. In many diabetic patients, however, all of the pancreatic stem cells may have been used up after only 3-5 years of disease. Thus, beta cell replacement therapies are likely to be required for the cure of the vast majority of established Type 1 diabetic patients. Pancreatic islet transplantation is one possible therapy but it is widely appreciated that the supply of human islets for transplantation will never meet the existing need. In addition, after islet transplantation, the patients need to take immunosuppressive drugs to prevent rejection throughout their life. An alternative therapy is to transplant beta cells. In this case, the cells surface can be treated to prevent rejection (another major discovery from Dr. Faustman's laboratory) and no immunosuppression is necessary.


Stem Cells (light shade) in a
Pancreatic Islet
The team of investigators at MGH have isolated these stem cells and found that they will proliferate rapidly outside of the body, in cell culture. They are also able to make them differentiate into beta cells by the addition of certain hormones and growth factors, and have implanted them into mice without rejection. One essential hormone needed for their differentiation into beta cells is GLP-1, which was first discovered by Dr. Habener and his colleagues several years ago.



In this work, the MGH team has identified a source of new human beta cells which may, in the future, be given to patients after their autoimmunity has been reversed. Before that can happen, the investigators will have to develop methods to isolate and grow pancreatic stem cells in quantity and to guide their development into beta cells more efficiently. Then these cells must effectively reverse diabetes in animal models before they can be considered as a suitable treatment for humans.


Conclusion
It is a leap of faith for any research team to proclaim that that a cure for Type 1 diabetes is in sight. A modifying statement saying the cure may be in sight would be more prudent, of course. But such a modifier would not reflect the enthusiasm the MGH Diabetes Center investigators are trying to contain over these discoveries.


Adding to the confidence behind these discoveries is the growing realization that the defective T cell believed to cause Type 1 diabetes, may in fact also cause other autoimmune diseases such as lupus, rheumatoid arthritis, and multiple sclerosis. The implications that may emerge from this research may extend well beyond diabetes alone. It may come to pass that the cause of many devastating autoimmune diseases have one cause that could be likened to having a loaded gun. The gun (defective T cell selection), selects different targets to destroy in different people, for reasons not yet understood. But what is important about this research is that there appears to be a way to disarm and remove the gun, permanently.


The multidisciplinary scientific team of the MGH Diabetes Center have arrived at a seldom seen position of being able to look into the future and see how these complimentary discoveries that may lead to a permanent cure to Type 1 diabetes, and possibly other autoimmune diseases.
MGH biomedical research as a whole attracts more NIH funding than any hospital in the country. In fact, the MGH Diabetes Program has attracted significant NIH and foundation support; current annual funding exceeds $13 million. Some of their most significant work, however, has been conducted "at the margin", without direct NIH funding support. If at all, it has been supported directly by philanthropic gifts.


The day has now come when philanthropic support may make the difference that will bring a cure for type 1 diabetes to human clinical trials. It is not an accident that lightning has struck, not once, but twice at the Diabetes Center at MGH. For the moment, please allow yourself to be open to the possibility that a cure for Type 1 diabetes - - for those who now have it and who are likely to become afflicted - - will be available with further research to bring the discoveries in mice to new medical treatments.



Source: http://www.mgh.harvard.edu/depts/dia...e1research.htm

Yes gfy can raise 1 million dollars but that money won't secure this site helping to cure any diseases just gives aid

What's his view on the porn community?

????????

The hardest part will be getting all these clowns on GFY to work together to raise the money.

you're telling me that 1 out of 4 americans have diabetes??

I can contribute $5 for a good cause...

I hope this little amount helps...

:thumbsup :thumbsup :thumbsup

you couldnt get enough gfy members to raise a flag pole let alone 1 million dollars

Don't think its going to happen. Best of luck.

1 in 4 have it yes, 90% of those are type 2, 10% are the severe type 1.

:1orglaugh :1orglaugh :1orglaugh

bumpy

bump bump

:1orglaugh too funny.


But this sounds pretty damn cool, a cure would be nice to see for sure!

Any industry can donate $1m

bump bump bump

You can say that again, its sad to see most people don't look at the bigger picture and see what this for example could do for the industry (not even going to talk about the disease itself).

Its normal to blow thousands in Expo's boths but not to help such causes which effects would be much better for all of us!

Bump. Interesting that she was the first one to cure it in mice, yet people are not throwing money at her left and right for human trials. Makes you wonder...

Recently compiled data show that approximately 150 million people have diabetes mellitus worldwide, and that this number may well double by the year 2025 (source http://www.who.int/mediacentre/facts.../en/index.html)

test strips for checking blood sugar - 1.00 each x 4 times a day - you do the math for that alone then think about the cost of meds on top of that

Would she accept it, if it was raised?

she is trying to start human trials now.
she would accept it, her goal is to make an inexpensive treatment as soon as possible

The world is overcrowded.
Various terminal deseases are needed because they act as population control.

If this cure used stem cells or aborted feti it would be perfect as a "fuck you" to the right wing.

:1orglaugh :1orglaugh

1m? seems impossible to me

the cure does use stem cells but not embryonic stem cells.
every person has stem cells.

it worked by first suppressing the bodys auto immune reaction to destroy the pancreatic cells then by injecting healthy stem cells into the organ. stem cells are "copy making" cells, for example, a mouse lost most of its tail, stem cells were injected into the remaining part, these cells then read the "blueprint" of the tail and actually regenerated a new one.

these cells can be used to regenerate the pancreas.

stem cells can be extracted from the person taking the treatment, usually from their bone marrow which eliminates the chance of rejection or taking of anti rejection drugs which are worse than the disease itself.


madcat, you are a peice of shit and i hope you get a disease like this

damn thats SOOO sad! :( too bad im not TOO RICH to help on my own =\

All you need is 10,000 to donate $100 each.
Or 1,000 to donate $1,000 each.

And so on.. But I highly doubt GFY could raise $1 million. 90% of people on here probably don't even do this full time.

who will donate 100 then?

if this lady actually could prove she had a damn cure, the funding would be there :2 cents:

Diabetes is a fat person's disease. How many diabetics you see in zambia? Put down the cheeseburgers fat people.

It sounds too good to be true. And what's with the glamour picture?

http://www.reachforthecure.org/

http://www.womenshealthresearch.org/about/faustman.htm

My husband is diabetic, as is his father and I want as badly as anyone to believe in a cure, which makes me all the more wary of being taken advantage of. The last thing I'd want to do is delay a REAL cure; It seems apparent that this doctor IS on the track but who's datezonline? Can anyone vouch for him?

The research appears to be real; it's genuinely backed by the iacocca foundation and there seems to be no one denying the fact that she HAS cured diabetes in mice. :eek7

Don't you hate it when you put time and effort into researching an intelligent post and someone posts a retarded comment like this right next to you?

25% of people in the US have type 1 Diabetes?

I dont think so.....

I think he has his point, though not so smooth in delivering it.

ok just for the idiot.

type 1 is caused by an infection, the bodys auto immune response is to kill than infection but in the process kills the wrong cells, the beta cells in the pancreas. the pancreas secretes insulin to balance glucose in the blood. if the glucose is to high you get hyperglycemia and ketone acidosis and go into a coma and die, if its too low you get hypoglycemia and go into a coma and die. type 1 or juvinile diabetes affects people from birth, are you saying that 3 month old baby was eating too many cheese burgers?

type 2 diabetes is caused by the bodys inability to break down insulin for it to be accepted by muscles and they generally have to manage it by diet and excersize. which helps them a lot, but is of no help to type 1.
sure living a bad lifestyle contributes but does not cause it.

and i never said 25% have type 1, morons should learn to read, 25% have it and 90% are type 2.

and by the way "low quality moron", 40% of people in southern india have type 1, they live on less than $2 a day, how many cheese burgers do you think they eat?