Cancer Curing Blood - GoFuckYourself.com

clickhappy · 06-07-2006, 10:16 AM

Cancer Curing Blood
SciCentral News ^ | June 7, 2006 | by Eva Gladek and Joyce Gramza

It's a discovery in animals that would change everything if it turns out to be true in people. An injection of blood cells from cancer-resistant mice cures cancer in ordinary mice. As this ScienCentral News video explains, there may be a way to identify cancer-resistant people.

The End of Cancer?

A universal treatment that would work against any type of cancer has always seemed like a far-fetched fantasy. But now researchers at Wake Forest University have made a discovery in mice that might one day lead to a "magic bullet" against human cancers if it proves to be true in people. Several years ago, the researchers identified a rare strain of mouse immune to high, usually lethal doses of cancer cells. Now they have shown that not only are these mice cancer-resistant, but their immune cells are also capable of curing normal, non-resistant mice of any type of advanced cancer.

As reported in Proceedings of the National Academy of Sciences, lead researcher Zheng Cui and his team injected white blood cells from the cancer-resistant mice into normal mice with aggressive cancers that should have killed them in two to three weeks. Instead, their cancer disappeared.

"Cancer cells had already developed a large tumor in the mice, and at a different place [than] where we put the immune cells in," says Cui, "That would require the immune cells to find them at a different part of the body and then track them down to the site and destroy the cancer cells."

The researchers have bred a large colony of the cancer-resistant mice, all from one mouse they discovered in 1999.

In previous studies the team showed that the resistant mice can survive very large doses ? up to 3 billion cells ? of any kind of cancer. This resistance is passed on genetically in a "perfect Medelian single dominant gene pattern," says Cui, since the trait is transmitted to roughly half of each resistant-mouse's offspring. On this basis the scientists believe the resistance mutation must be in a single gene.

But after seven years of searching for the gene, the researchers have yet to identify it. "There isn't any reason to think it's not a single gene, it just turns out that analysis of that genetics is somewhat more complex than one would have predicted," says pathologist Mark Willingham, a co-author of the paper.

Their past work also clearly showed that the gene worked by somehow activating the immune systems of these resistant mice to selectively target cancer cells. Their most recent research confirms that the immune cells that do the cancer killing belong to the innate immune system. They recognize cancer cells as foreign and attack them without having any prior exposure to them.

"I think the surprise from this mouse model is that it involves a part of the immune system that would not have been predicted," says Willingham.

When the researchers isolated different types of innate immune system cells from the resistant mice and tested them against cancer cells, they got another surprise: the cancer resistance was not confined to just one type of immune cell. "All [the types] can be independently killing [cancer] cells without the other subtypes present," says Cui.

A funder of the study, the Cancer Research Institute, which backs immunological approaches to cancer diagnosis and treatment, is funding collaborations with Bruce Beutler, M.D., an immunogeneticist at the Scripps Research Institute, to help search for the gene, and with Robert D. Schreiber, Ph.D., a molecular immunopathologist at the Washington University School of Medicine in St. Louis, who will test the cancer-resistant cells on his mouse models of naturally arising cancers.

Unconventional ideas

The researchers also developed a blood test that can identify the cancer-resistant mice without having to challenge them with cancer. They hope a similar test might help find and study cancer-resistance in people.

"If this were to be the same in humans we could simply identify cancer-resistant humans and to do the blood transfusion or white blood cell transfusion without even knowing the mechanism to find out whether it will work or not," says Cui, "So that's obviously on everybody's mind."

The researchers say they've heard from many cancer patients and their loved ones excited about the tantalizing possibility that blood and bone marrow banks might also contain cancer curing cells. Cui points out that it could take years to find the gene, and many more to develop and test drugs that target it. In the meantime, his team has begun to test blood samples from healthy people, and have found a wide range of cancer-killing activity in humans. "We are forced and compelled to do this kind of experiment ... I think it's our responsibility as cancer researchers," Cui says. But he also acknowledges that he is having a hard time getting funding for this approach. "It's obviously a very unconventional way of doing science nowadays," he says. "It's not mechanism-based ... it?s simple mimicry of what happened in the mice."

Indeed, cell biologist Jill O'Donnell-Tormey, executive director of the Cancer Research Institute, says it's important to first understand the genetic and biological basis of these cancer killing blood cells.

"There is some indication that a similar mechanism that we're seeing in these remarkable mice are also present in humans but we think we have a ways to go in terms of doing a good deal of research before we can actually answer that question," she says.

Cui says he would like to pursue both the conventional and unconventional approaches. "We think there might actually be a possibility we could do it without knowing the mechanism," he says, "but of course by knowing the mechanism you could devise many other options, so if one thing doesn't work then you can also find different ways using the same concept. So we think both directions are important."

He notes, however, that if the cell-donation approach were to work in people, it would not need to go through a long FDA approval process. "All the delivery mechanisms are already in place and all the ethical regulations for that direction are already in place. So if we can identify cancer-resistant humans then they could start treating them tomorrow if someone wants to pay for it."

This most recent finding by Cui and his team was published in the May 16, 2006 Proceedings of the National Academy of Sciences (PNAS). The research is funded by the Cancer Research Institute (CRI), National Cancer Institute (NCI), and the Charlotte Geyer Foundation.

J. Falcon · 06-07-2006, 10:18 AM

Can you offer a link?

xclusive · 06-07-2006, 10:19 AM

that would be great news

clickhappy · 06-07-2006, 10:23 AM

Quote:

Originally Posted by J. Falcon

Can you offer a link?

http://www.pnas.org/cgi/content/full/103/20/7753

clickhappy · 06-07-2006, 10:25 AM

Heres an image of it
http://www.pnas.org/content/vol103/i...621720004.jpeg

tumor was gone in a month

ne0 · 06-07-2006, 10:33 AM

nice news, i hope everything go ok and they find a mice aids resistant too ;)

fetishblog · 06-07-2006, 10:35 AM

That's awesome! Hopefully it works as well in humans as it does in mice!

Brujah · 06-07-2006, 10:47 AM

Awesome. Now more mice won't have to suffer through chemotherapy.

Elli · 06-07-2006, 10:48 AM

$10 says it was a cylon mouse.

WebairGerard · 06-07-2006, 11:15 AM

that is pretty amazing. let's hope it works in humans too.

nancycash(dot)com · 06-07-2006, 11:26 AM

good news for people with cancer.

madawgz · 06-07-2006, 12:24 PM

great!

hopefully it works out!

Dagwolf · 06-07-2006, 12:48 PM

Yeah, I've seen this before. It's really exciting... It falls into the "too good to be true" category for now.

Double L · 06-07-2006, 12:58 PM

Am I being too pessimistic to think that drug companies would kill such a thing if true? I mean, there's no money in the cure compared to the high nagging treatment costs... So unless a solution like this arose and the drug companies could make it a high cost (not just something the patent would run out on)... Ah fuck it.. thats all too negative logic. I love the dream that something like the article could become a reality.

CaptainHowdy · 06-07-2006, 01:34 PM

That's simply amazing...

!,

Phoenix · 06-07-2006, 01:38 PM

Quote:

Originally Posted by Double L

Am I being too pessimistic to think that drug companies would kill such a thing if true? I mean, there's no money in the cure compared to the high nagging treatment costs... So unless a solution like this arose and the drug companies could make it a high cost (not just something the patent would run out on)... Ah fuck it.. thats all too negative logic. I love the dream that something like the article could become a reality.

that logic doesnt hold up unless there was only one company

they all try to outdo each other...so one will take the money on the cure and be known throught the world for it..thusly they will get major bucks for research on other illness

and i thought i was a conspiracy nut ;)

Thomas1007 · 06-07-2006, 01:47 PM

wow, lets hope this can be developed in the future for people.

Double L · 06-07-2006, 02:17 PM

Quote:

Originally Posted by Phoenix

that logic doesnt hold up unless there was only one company

they all try to outdo each other...so one will take the money on the cure and be known throught the world for it..thusly they will get major bucks for research on other illness

and i thought i was a conspiracy nut ;)

I am a conspiracy nut so I still don't buy your theory

Matiz · 06-07-2006, 02:42 PM

Quote:

Originally Posted by Double L

Am I being too pessimistic to think that drug companies would kill such a thing if true? I mean, there's no money in the cure compared to the high nagging treatment costs... So unless a solution like this arose and the drug companies could make it a high cost (not just something the patent would run out on)... Ah fuck it.. thats all too negative logic. I love the dream that something like the article could become a reality.

Don't worry, they would find a way to cash in on a cure.

sweetgirl2006 · 06-07-2006, 02:44 PM

Yeah that is good news

Titan · 06-07-2006, 02:48 PM

Sweet all we have to do is expose thousands of people to cancer till we find one with the super cancer resistance gene (if it exists in people) and then breed this person a bunch. Take this dude and his offspring and transfer the cells to other people... uh... anyone see a problem with this? Reminds me of the movie unbreakable.

G-Rotica · 06-07-2006, 02:50 PM

bring on the marlboros

TheJimmy · 06-07-2006, 07:04 PM

thanks for the post, very interesting read...

reynold · 06-07-2006, 10:01 PM

Another brakthrough in medical society. I wish this study would have a positive result in the end..

06-07-2006, 10:16 AM	#1
clickhappy Confirmed User Industry Role: Join Date: Mar 2004 Posts: 4,027	Cancer Curing Blood Cancer Curing Blood SciCentral News ^ \| June 7, 2006 \| by Eva Gladek and Joyce Gramza It's a discovery in animals that would change everything if it turns out to be true in people. An injection of blood cells from cancer-resistant mice cures cancer in ordinary mice. As this ScienCentral News video explains, there may be a way to identify cancer-resistant people. The End of Cancer? A universal treatment that would work against any type of cancer has always seemed like a far-fetched fantasy. But now researchers at Wake Forest University have made a discovery in mice that might one day lead to a "magic bullet" against human cancers if it proves to be true in people. Several years ago, the researchers identified a rare strain of mouse immune to high, usually lethal doses of cancer cells. Now they have shown that not only are these mice cancer-resistant, but their immune cells are also capable of curing normal, non-resistant mice of any type of advanced cancer. As reported in Proceedings of the National Academy of Sciences, lead researcher Zheng Cui and his team injected white blood cells from the cancer-resistant mice into normal mice with aggressive cancers that should have killed them in two to three weeks. Instead, their cancer disappeared. "Cancer cells had already developed a large tumor in the mice, and at a different place [than] where we put the immune cells in," says Cui, "That would require the immune cells to find them at a different part of the body and then track them down to the site and destroy the cancer cells." The researchers have bred a large colony of the cancer-resistant mice, all from one mouse they discovered in 1999. In previous studies the team showed that the resistant mice can survive very large doses ? up to 3 billion cells ? of any kind of cancer. This resistance is passed on genetically in a "perfect Medelian single dominant gene pattern," says Cui, since the trait is transmitted to roughly half of each resistant-mouse's offspring. On this basis the scientists believe the resistance mutation must be in a single gene. But after seven years of searching for the gene, the researchers have yet to identify it. "There isn't any reason to think it's not a single gene, it just turns out that analysis of that genetics is somewhat more complex than one would have predicted," says pathologist Mark Willingham, a co-author of the paper. Their past work also clearly showed that the gene worked by somehow activating the immune systems of these resistant mice to selectively target cancer cells. Their most recent research confirms that the immune cells that do the cancer killing belong to the innate immune system. They recognize cancer cells as foreign and attack them without having any prior exposure to them. "I think the surprise from this mouse model is that it involves a part of the immune system that would not have been predicted," says Willingham. When the researchers isolated different types of innate immune system cells from the resistant mice and tested them against cancer cells, they got another surprise: the cancer resistance was not confined to just one type of immune cell. "All [the types] can be independently killing [cancer] cells without the other subtypes present," says Cui. A funder of the study, the Cancer Research Institute, which backs immunological approaches to cancer diagnosis and treatment, is funding collaborations with Bruce Beutler, M.D., an immunogeneticist at the Scripps Research Institute, to help search for the gene, and with Robert D. Schreiber, Ph.D., a molecular immunopathologist at the Washington University School of Medicine in St. Louis, who will test the cancer-resistant cells on his mouse models of naturally arising cancers. Unconventional ideas The researchers also developed a blood test that can identify the cancer-resistant mice without having to challenge them with cancer. They hope a similar test might help find and study cancer-resistance in people. "If this were to be the same in humans we could simply identify cancer-resistant humans and to do the blood transfusion or white blood cell transfusion without even knowing the mechanism to find out whether it will work or not," says Cui, "So that's obviously on everybody's mind." The researchers say they've heard from many cancer patients and their loved ones excited about the tantalizing possibility that blood and bone marrow banks might also contain cancer curing cells. Cui points out that it could take years to find the gene, and many more to develop and test drugs that target it. In the meantime, his team has begun to test blood samples from healthy people, and have found a wide range of cancer-killing activity in humans. "We are forced and compelled to do this kind of experiment ... I think it's our responsibility as cancer researchers," Cui says. But he also acknowledges that he is having a hard time getting funding for this approach. "It's obviously a very unconventional way of doing science nowadays," he says. "It's not mechanism-based ... it?s simple mimicry of what happened in the mice." Indeed, cell biologist Jill O'Donnell-Tormey, executive director of the Cancer Research Institute, says it's important to first understand the genetic and biological basis of these cancer killing blood cells. "There is some indication that a similar mechanism that we're seeing in these remarkable mice are also present in humans but we think we have a ways to go in terms of doing a good deal of research before we can actually answer that question," she says. Cui says he would like to pursue both the conventional and unconventional approaches. "We think there might actually be a possibility we could do it without knowing the mechanism," he says, "but of course by knowing the mechanism you could devise many other options, so if one thing doesn't work then you can also find different ways using the same concept. So we think both directions are important." He notes, however, that if the cell-donation approach were to work in people, it would not need to go through a long FDA approval process. "All the delivery mechanisms are already in place and all the ethical regulations for that direction are already in place. So if we can identify cancer-resistant humans then they could start treating them tomorrow if someone wants to pay for it." This most recent finding by Cui and his team was published in the May 16, 2006 Proceedings of the National Academy of Sciences (PNAS). The research is funded by the Cancer Research Institute (CRI), National Cancer Institute (NCI), and the Charlotte Geyer Foundation.

06-07-2006, 10:18 AM	#2
J. Falcon www.AdultCopywriters.com Industry Role: Join Date: May 2006 Posts: 31,618	Can you offer a link? __________________ Adult Copywriters SEO Content for Porn Sites sales at adultcopywriters dot com

06-07-2006, 10:19 AM	#3
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06-07-2006, 10:33 AM	#6
ne0 Confirmed User Join Date: May 2006 Location: brazil Posts: 781	nice news, i hope everything go ok and they find a mice aids resistant too ;) __________________ hai2u

06-07-2006, 10:35 AM	#7
fetishblog Confirmed User Join Date: Sep 2005 Location: Your mom is my favorite pornstar!#% Posts: 5,995	That's awesome! Hopefully it works as well in humans as it does in mice! __________________ Fling.com doesn't steal your traffic and sales unlike some other dating companies. I promote them, and so should you!

06-07-2006, 10:25 AM	#5
clickhappy Confirmed User Industry Role: Join Date: Mar 2004 Posts: 4,027	Heres an image of it http://www.pnas.org/content/vol103/i...621720004.jpeg tumor was gone in a month

06-07-2006, 10:47 AM	#8
Brujah Beer Money Baron Industry Role: Join Date: Jan 2001 Location: brujah / gmail Posts: 22,157	Awesome. Now more mice won't have to suffer through chemotherapy. __________________ Free Premium Domain Lists and Tools at Clickmojo.com For Sale: Obscenity.com

06-07-2006, 10:48 AM	#9
Elli Reach for those stars! Industry Role: Join Date: Apr 2003 Location: Vancouver, BC Posts: 17,991	$10 says it was a cylon mouse. __________________ email: [email protected]

06-07-2006, 11:15 AM	#10
WebairGerard Confirmed User Industry Role: Join Date: Sep 2005 Posts: 8,113	that is pretty amazing. let's hope it works in humans too. __________________

06-07-2006, 11:26 AM	#11
nancycash(dot)com Confirmed User Join Date: Jun 2006 Posts: 208	good news for people with cancer. __________________ NEW SOLO GIRL NANCY TITS + NANCY PUSSY = $CASH$

06-07-2006, 12:24 PM	#12
madawgz 8.8.8.8 Industry Role: Join Date: Mar 2006 Location: Noordermarkt Posts: 30,509	great! hopefully it works out! __________________ TAEMDLRMSKRJIXMRLSMRJ.

06-07-2006, 12:48 PM	#13
Dagwolf President of Canada Join Date: Sep 2003 Location: Leaving Hell, Entering Limbo Posts: 23,141	Yeah, I've seen this before. It's really exciting... It falls into the "too good to be true" category for now. __________________ Sleep well, and dream of large women.

06-07-2006, 12:58 PM	#14
Double L Confirmed User Join Date: Nov 2004 Location: US Posts: 349	Am I being too pessimistic to think that drug companies would kill such a thing if true? I mean, there's no money in the cure compared to the high nagging treatment costs... So unless a solution like this arose and the drug companies could make it a high cost (not just something the patent would run out on)... Ah fuck it.. thats all too negative logic. I love the dream that something like the article could become a reality.

06-07-2006, 01:34 PM	#15
CaptainHowdy Too lazy to set a custom title Industry Role: Join Date: Dec 2004 Location: Happy in the dark. Posts: 93,606	That's simply amazing... !, __________________ Sig Coming Soon

06-07-2006, 01:47 PM	#17
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06-07-2006, 02:44 PM	#20
sweetgirl2006 Confirmed User Join Date: May 2006 Posts: 1,194	Yeah that is good news __________________

06-07-2006, 02:48 PM	#21
Titan Confirmed User Join Date: Jun 2002 Location: teencash.com Posts: 994	Sweet all we have to do is expose thousands of people to cancer till we find one with the super cancer resistance gene (if it exists in people) and then breed this person a bunch. Take this dude and his offspring and transfer the cells to other people... uh... anyone see a problem with this? Reminds me of the movie unbreakable. __________________ TEEN CASH - EXCLUSIVE TEEN NICHE REALITY SITES Check out our Newest Site: Teen Porno Pass - Free Hosted Galleries, Flash Galleries, Tube Content, & Great Support Sample Galleries: Movie Gallery 1 Flash Gallery 1 Pic Gallery 1

06-07-2006, 02:50 PM	#22
G-Rotica Confirmed User Industry Role: Join Date: Aug 2005 Location: Austin, TX Posts: 4,258	bring on the marlboros __________________

06-07-2006, 07:04 PM	#23
TheJimmy ICQ- five seven 0 2 5 5 0 Join Date: Jan 2001 Posts: 10,747	thanks for the post, very interesting read... __________________ Investor with 5m - 15m USD to invest. Do you have a site or network of sites earning 50k - 200k a month income? Email your contact and preliminary data to: domain.cashventures (at) gmail.com....Please...no tire kickers...serious offers and inquiries only.

06-07-2006, 10:01 PM	#24
reynold Too lazy to set a custom title Join Date: Oct 2002 Location: Global Traveler Posts: 51,271	Another brakthrough in medical society. I wish this study would have a positive result in the end..