Designers: Which colors are easiest on the eyes?

[cambaby]

I realize books are printed black on white, is this the best color for web design too? Which color combos do you think are easiest on the eyes.

[psili]

Maddox would say a black background with large white text.

Did some research while doing an auto insurance company's affiliate web interface and came up with a desaturated grey-yellow with black / blue text. However, I've always liked a nice CCCCCC with black text for IDE interfaces.

Want to fuck someone over, go with red on blue or vice versus.

[psili]

I realize books are printed black on white, is this the best color for web design too?

I'm not sure about the correct terms, but ambient light is reflected off of a book's pages, which is different then the light broadcast to the eyes via a monitor. Personally, I think a white background with black text on a monitor is a bit harsh, especially when viewing it for extended periods.

[chaze]

I like white text with a dark grey background.

Blue sublimely makes people think easy or calm.

[Playa-Deak]

Dark text on a light background holds a readers attention longer... The shades of grey is always a good choice IMO...

[cambaby]

I like white text with a dark grey background.

Blue sublimely makes people think easy or calm.

Kind of like current GFY theme ehh?
Actually I had a website with a darker blue background and #eeeeee as the font color and it always did make me feel calm too.