How do antidepressants work ?

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  • DarkJedi
    No Refunds Issued.
    • Feb 2001
    • 28301

    #1

    How do antidepressants work ?

    how do thay actually help depressed ppl ?
  • Gutterboy
    So Fucking Banned
    • Jul 2002
    • 4751

    #2
    In a variety of manners, most of which are too complicated to type out.

    If you really want to research the subject, look up the Doc's prescribing information (not the patient pamphlets) for an SSRI. Paxil or Prozac maybe. They will tell you exactly how the drug is metabolized and what it does.
    Last edited by Gutterboy; 08-13-2003, 07:42 AM.

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    • Fletch XXX
      GFY HALL OF FAME DAMMIT!!!
      • Jan 2002
      • 60840

      #3
      depressants are better.

      cold beer over Paxil any fucking day.


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      • Gutterboy
        So Fucking Banned
        • Jul 2002
        • 4751

        #4
        Originally posted by Fletch XXX
        depressants are better.

        cold beer over Paxil any fucking day.

        Why not both?

        I do it all the time, and look at how sane I am.

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        • reynold
          Too lazy to set a custom title
          • Oct 2002
          • 51271

          #5
          There is a disbalance in certain neurotransmitters in the brain. Neurotransmitters transmit signals from one neuron to another. Antidepressiva increase the serotonin (one of the neurotransmitters) concentration e.g. by inhibiting reuptake.

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          • Gutterboy
            So Fucking Banned
            • Jul 2002
            • 4751

            #6
            Here ya go: http://us.gsk.com/products/assets/us_paxil.pdf

            Everything you wanted to know about Paxil but never dared to ask.

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            • Katlicious72
              Confirmed User
              • Jul 2003
              • 1665

              #7
              When you get depressed frequently you are not producing enough seratonin to combat your sadness, moodiness, fatigue, etc. Anti-Depressants help with this chemical imbalance and gets you back on track. If you are to try an anti-depressant, try Effexor. Paxil and Prozac have very harsh side effects. One of my friends is on Effexor and has really changed alot from how she once was. I would talk to my Psychiatrist first to find out exactly how long you need to be on the medication and discuss dosage. The average depressed person should be monitored regularly by their doctor to make sure your medicine is working for you.
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              • LeeNoga
                Confirmed User
                • Jul 2001
                • 3043

                #8
                How do anti-depressants work? They wreck your sexual function which warrants remaining on them long term for the additional depression.

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                • Katlicious72
                  Confirmed User
                  • Jul 2003
                  • 1665

                  #9
                  Originally posted by LeeNoga
                  How do anti-depressants work? They wreck your sexual function which warrants remaining on them long term for the additional depression.
                  Good one
                  I gave the medical synopsis but yours is great!
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                  • Gutterboy
                    So Fucking Banned
                    • Jul 2002
                    • 4751

                    #10
                    Originally posted by Katlicious72
                    If you are to try an anti-depressant, try Effexor. Paxil and Prozac have very harsh side effects.
                    You can't make generalizations like that. Some take Paxil and experience few side effects (myself included), and some people take Effexor and find its effects intolerable. The opposite situation is also true. We're all an experiment of one, and no one can predict how they're going to react to a drug - especially one which fucks with your brain chemistry - until they try it themselves.

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                    • Katlicious72
                      Confirmed User
                      • Jul 2003
                      • 1665

                      #11
                      Originally posted by Gutterboy


                      You can't make generalizations like that. Some take Paxil and experience few side effects (myself included), and some people take Effexor and experience many. The opposite situation is also true. We're all an experiment of one, and no one can predict how they're going to react to a drug, especially one which significantly alters brain chemistry, until they try it themselves.
                      I was just giving my opinion. It's really up to the individual to take what they want. Maybe I should have "said" that and not "generalized". And that's another reason i told the person to talk to "their" doctor.
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                      • Gimmy
                        Confirmed User
                        • Jul 2002
                        • 1069

                        #12
                        As many people said, the anti-depressants inhibit the re-uptake of neurotransmitters like Serotonin. Neurotransmitters are chemicals used to transport a nerve signal that was propagated in the previous neuron (nerve cell) via an electrical signal. But the bad thing about the anti-depressants, is that they inhibit the receptors and hence, the uptake of Serotonin and over time the receptors on the nerve cells become unresponsive to Serotonin, cause there is so much in the synaptic space. So over time your body needs much much more lelvel of Serotonin to produce a nerve signal. That is the flaw in the anti-depressants. I mean, sunlight has been proven to increase the Serotonin levels naturally, why take those anti-depressants that make the situation even worse over time. Ok, I am tired of typing.

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                        • polish_aristocrat
                          Too lazy to set a custom title
                          • Jul 2002
                          • 40377

                          #13
                          Everytime I see a thread on GFY with "Visa" in it, I take an antidepressant and wait 30 minutes before i read it.
                          I don't use ICQ anymore.

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                          • Gutterboy
                            So Fucking Banned
                            • Jul 2002
                            • 4751

                            #14
                            Originally posted by Gimmy
                            But the bad thing about the anti-depressants, is that they inhibit the receptors and hence, the uptake of Serotonin and over time the receptors on the nerve cells become unresponsive to Serotonin, cause there is so much in the synaptic space. So over time your body needs much much more lelvel of Serotonin to produce a nerve signal.
                            If that were true, all SSRI's would eventually stop working suddenly when the brains ability to manufacture serotonin was exceeded by the receptors insensitivity to it. Considering the number of people taking these drugs, the pattern would be picked up quickly.
                            Last edited by Gutterboy; 08-13-2003, 08:09 AM.

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                            • Rui
                              web
                              • Dec 2001
                              • 9533

                              #15
                              they do their job but depends on the people some improve alot others don't...

                              BTW if you are taking PAXIL forget about having decent sex

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                              • Gimmy
                                Confirmed User
                                • Jul 2002
                                • 1069

                                #16
                                Originally posted by Gutterboy


                                If that were true, all SSRI's would eventually stop working suddenly when the brains ability to manufacture serotonin was exceeded by the receptors insensitivity to it. Considering the number of people taking these drugs, the pattern would be picked up quickly.
                                Well, didn't you hear about Prozac? And the same flaws are going to happen to all those new anti-depressant drugs. Any drug or hormone therapy that disrupts the body's neurotransmitter or hormone levels will disrupt the body's equilibrium. Those drugs can't fool the body, by doing one thing, they cause a whole different reponse, like making the receptors on post-synaptic neurons incensitive to amounts of Serotonin, that were enough in the past to generate a nerve signal. So what happens when you stop taking the anti-depressants, your body generates the same amounts of Serotonin, but it is not enough to cause a nerve response and the person goes into even more depression.
                                THe best way to battle depression, is to exersice, go outside, talk with others ect...
                                Last edited by Gimmy; 08-13-2003, 08:24 AM.

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                                • jungar
                                  Confirmed User
                                  • Jul 2003
                                  • 377

                                  #17
                                  Originally posted by Gimmy



                                  THe best way to battle depression, is to exersice, go outside, talk with others ect...
                                  Actually, the best way to treat depression is with a combined regimen of pharmacological agents, behavioral therapy, cognitive therapy and social support.

                                  There are several pharmacological agents available. The best one to take is the one that works for you, people have different reactions to drugs; some drugs work with some people, others with other people ? these drugs are prescribed on a trial and error basis.

                                  Behavioral therapy essentially helps one cope with stress. People who suffer from depression learn behavioral techniques to help them deal with various environmental ?triggers? of depression.

                                  Cognitive therapy, which typically complements behavioral therapy, teaches patients to reevaluate their respective situation. Essentially, it is an effort to change their respective negative perspectives into positive ones.

                                  Social Support therapy is when you bring in family and friends into therapy so that they can learn how to help the patient at home. This type of therapy, like cognitive-behavioral therapy, is based on the premise that the environment contributes to psychopathology. If your family and friends understand this, they can learn to change their own behavior to help the depressed individual adapt to their environment in a wholesome manner.

                                  A combination of these types of therapy has been shown to help the patient recover the most.

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                                  • Gutterboy
                                    So Fucking Banned
                                    • Jul 2002
                                    • 4751

                                    #18
                                    Originally posted by Gimmy


                                    Well, didn't you hear about Prozac? And the same flaws are going to happen to all those new anti-depressant drugs. Any drug or hormone therapy that disrupts the body's neurotransmitter or hormone levels will disrupt the body's equilibrium. Those drugs can't fool the body, by doing one thing, they cause a whole different reponse, like making the receptors on post-synaptic neurons incensitive to amounts of Serotonin, that were enough in the past to generate a nerve signal. So what happens when you stop taking the anti-depressants, your body generates the same amounts of Serotonin, but it is not enough to cause a nerve response and the person goes into even more depression.
                                    THe best way to battle depression, is to exersice, go outside, talk with others ect...
                                    Now I'm sure you have no idea what the fuck you're babbling on about.
                                    Last edited by Gutterboy; 08-13-2003, 09:43 AM.

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                                    • DarkJedi
                                      No Refunds Issued.
                                      • Feb 2001
                                      • 28301

                                      #19
                                      i don't know,

                                      say i'm a 40 y.o. virgin, live parents, got $0.27 in my bank account and have a 3" cock - how the hell antidepressants going to help me ?

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                                      • polish_aristocrat
                                        Too lazy to set a custom title
                                        • Jul 2002
                                        • 40377

                                        #20
                                        LOL
                                        I don't use ICQ anymore.

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                                        • Gimmy
                                          Confirmed User
                                          • Jul 2002
                                          • 1069

                                          #21
                                          Originally posted by Gutterboy


                                          Now I'm sure you have no idea what the fuck you're babbling on about.
                                          I think having a Master's in Biology I know what I am blabbing around

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                                          • goBigtime
                                            Confirmed User
                                            • Nov 2002
                                            • 7761

                                            #22
                                            Originally posted by LeeNoga
                                            How do anti-depressants work? They wreck your sexual function which warrants remaining on them long term for the additional depression.

                                            Nah they wouldn't do that. They want to make you a better shiny happy person. What you're suggesting is that they want you dependent on their product(s) for the rest of your life.

                                            They want to HELP you, not hurt you.

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                                            • freeadultcontent
                                              Confirmed User
                                              • Oct 2002
                                              • 9976

                                              #23
                                              Many make you tired and you fall asleep, cant be depressed while your sleeping.

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                                              • goBigtime
                                                Confirmed User
                                                • Nov 2002
                                                • 7761

                                                #24
                                                Originally posted by goBigtime


                                                They want to HELP you, not hurt you.

                                                Oh and don't worry people, Nicotine is NOT addictive.

                                                These guys said so...



                                                So when you're ready to quit smoking and start leading a healthier life.. just stop buying them and you'll be all set

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                                                • Que?
                                                  Confirmed User
                                                  • Aug 2002
                                                  • 340

                                                  #25
                                                  You can get emotionally numb, not feeling much about anything.

                                                  might be nice for a while but it sucks in the long run, better to find other strategies to keep your spirits up. Porn fex
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                                                  • Gutterboy
                                                    So Fucking Banned
                                                    • Jul 2002
                                                    • 4751

                                                    #26
                                                    Originally posted by Gimmy


                                                    I think having a Master's in Biology I know what I am blabbing around
                                                    Except for the fact that none of the clincal trials on SSRI's agree with your ill informed speculations. I have an inkling though that the fact your theories don't correspond with reality won't dampen your ardor for anti-SSRI proselytizing.

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                                                    • Honeyslut
                                                      Confirmed User
                                                      • Jan 2001
                                                      • 6436

                                                      #27
                                                      Originally posted by Gutterboy


                                                      If that were true, all SSRI's would eventually stop working suddenly when the brains ability to manufacture serotonin was exceeded by the receptors insensitivity to it. Considering the number of people taking these drugs, the pattern would be picked up quickly.
                                                      I can guarantee you that a LARGE majority of people taking anti depressants are not depressed.

                                                      Doctors are too lazy to fix what is wrong and assume cause you have a bit of anixety that you need something like paxil.
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                                                      • Gutterboy
                                                        So Fucking Banned
                                                        • Jul 2002
                                                        • 4751

                                                        #28
                                                        Originally posted by Honeyslut


                                                        I can guarantee you that a LARGE majority of people taking anti depressants are not depressed.

                                                        Doctors are too lazy to fix what is wrong and assume cause you have a bit of anixety that you need something like paxil.
                                                        No doubt you are right, but the fact these things are overprescribed doesn't justify the amount of uninformed bashing going on. I've talked to quite a few people who probably should try one of these drugs out, but are scared because they've read a bunch of silly theories & heresay horror stories on the internet.

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                                                        • Honeyslut
                                                          Confirmed User
                                                          • Jan 2001
                                                          • 6436

                                                          #29
                                                          All I can tell you is PAXIL does not cure asthma, neck and jaw injuries..dumb ass doctors

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                                                          • Honeyslut
                                                            Confirmed User
                                                            • Jan 2001
                                                            • 6436

                                                            #30
                                                            Originally posted by Rui
                                                            they do their job but depends on the people some improve alot others don't...

                                                            BTW if you are taking PAXIL forget about having decent sex
                                                            Are you referring to men or women having sex ?
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                                                            • Gutterboy
                                                              So Fucking Banned
                                                              • Jul 2002
                                                              • 4751

                                                              #31
                                                              Originally posted by Honeyslut
                                                              All I can tell you is PAXIL does not cure asthma, neck and jaw injuries..dumb ass doctors

                                                              Yeah, but I bet you felt better about having them!

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                                                              • kelly
                                                                Confirmed User
                                                                • Jul 2002
                                                                • 901

                                                                #32
                                                                After being attacked earlier this year the police called for a doctor, I was prescribed anti-depressants and sleeping tabs, I chose to ditch them in favour of booze, works better for me.
                                                                http://www.thehungersite.com

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                                                                • Mishi
                                                                  Confirmed User
                                                                  • Feb 2002
                                                                  • 1054

                                                                  #33
                                                                  Unfortunately (or fortunately? Guess it depends on your point of view) patients need educate themselves these days. The last time I visited a doctor, I basically told him what he needed to prescribe for me, and he didn't argue. It was convenient, but not particularly confidence-inspiring.

                                                                  I miss the doctors that never actually existed in my lifetime - the housecall-making, drug-scorning, how's-your-family-asking geniuses of TVLand...ah, those were the days that weren't...
                                                                  Looking for PHP/MySQL solutions? Check out Cyboriginal - custom scripts, installation services and more.

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                                                                  • Honeyslut
                                                                    Confirmed User
                                                                    • Jan 2001
                                                                    • 6436

                                                                    #34
                                                                    Originally posted by Gutterboy


                                                                    Yeah, but I bet you felt better about having them!

                                                                    They don't work for my conditions..... Paxil is for anixety disorder and depression. I find it amazing on three different occasions doctors have given it to me thinking it will help..








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                                                                    • Gutterboy
                                                                      So Fucking Banned
                                                                      • Jul 2002
                                                                      • 4751

                                                                      #35
                                                                      Originally posted by Mishi
                                                                      Unfortunately (or fortunately? Guess it depends on your point of view) patients need educate themselves these days. The last time I visited a doctor, I basically told him what he needed to prescribe for me, and he didn't argue. It was convenient, but not particularly confidence-inspiring.

                                                                      I miss the doctors that never actually existed in my lifetime - the housecall-making, drug-scorning, how's-your-family-asking geniuses of TVLand...ah, those were the days that weren't...
                                                                      I know more about SSRI's & benzo's than 90% of the GP & IM physicians I've talked to. Unfortunately these are the same physicians who are prescribing SSRI's like rolaids these days. Its no big secret in the medical profession that many Doc's just don't like dealing with psych. patients, so they avoid the field like the plague.

                                                                      If you're considering these drugs, self education and shopping around for a knowledgable psychiatrist you can work with are invaluble.
                                                                      Last edited by Gutterboy; 08-14-2003, 12:26 AM.

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                                                                      • Gutterboy
                                                                        So Fucking Banned
                                                                        • Jul 2002
                                                                        • 4751

                                                                        #36
                                                                        Originally posted by Honeyslut


                                                                        They don't work for my conditions..... Paxil is for anixety disorder and depression. I find it amazing on three different occasions doctors have given it to me thinking it will help..
                                                                        It may be a not so subtle way of trying to tell you its all in your head.

                                                                        Edit: I'm not saying it is of course, but docs can be assholes too.

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                                                                        • Honeyslut
                                                                          Confirmed User
                                                                          • Jan 2001
                                                                          • 6436

                                                                          #37
                                                                          Originally posted by Gutterboy


                                                                          It may be a not so subtle way of trying to tell you its all in your head.

                                                                          Edit: I'm not saying it is of course, but docs can be assholes too.
                                                                          I have the allergy tests, xrays and medical letters to prove it is not in my head and the doctor has charts showing my blood pressure problems and family history.

                                                                          Any doctor who can look at my test and xrays and say nothing is wrong needs to go back to school..

                                                                          Are you sure you are not my mother ? She has told me the same shit all my life...

                                                                          It's in my head...

                                                                          LOL
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                                                                          • Honeyslut
                                                                            Confirmed User
                                                                            • Jan 2001
                                                                            • 6436

                                                                            #38
                                                                            Originally posted by Gutterboy


                                                                            It may be a not so subtle way of trying to tell you its all in your head.

                                                                            Edit: I'm not saying it is of course, but docs can be assholes too.
                                                                            edit: men doctors are assholes and wrong 98% of the time..
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                                                                            • Maru
                                                                              Confirmed User
                                                                              • Jul 2003
                                                                              • 918

                                                                              #39
                                                                              They want to make you a better shiny happy person. What you're suggesting is that they want you dependent on their product(s) for the rest of your life.

                                                                              They want to HELP you, not hurt you.
                                                                              Hey - I saw that!

                                                                              That was SARCASM. I didn't think that was allowed here....

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                                                                              • Honeyslut
                                                                                Confirmed User
                                                                                • Jan 2001
                                                                                • 6436

                                                                                #40
                                                                                Originally posted by Maru


                                                                                Hey - I saw that!

                                                                                That was SARCASM. I didn't think that was allowed here....

                                                                                hehehe
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                                                                                • Dravyk
                                                                                  Confirmed User
                                                                                  • Jan 2001
                                                                                  • 1202

                                                                                  #41
                                                                                  How do antidepressants work ?
                                                                                  I'd give you an answer, but I'm just too damned bummed to do so.
                                                                                  All Of 'Em

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                                                                                  • IMP^or^SNiTL.e
                                                                                    A/S/L .. I don't names.
                                                                                    • Aug 2003
                                                                                    • 1177

                                                                                    #42
                                                                                    its all a CIA conspiracy they dont know shit the doctors

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                                                                                    • jellohead
                                                                                      Confirmed User
                                                                                      • Apr 2003
                                                                                      • 154

                                                                                      #43
                                                                                      Originally posted by Katlicious72
                                                                                      When you get depressed frequently you are not producing enough seratonin to combat your sadness, moodiness, fatigue, etc. Anti-Depressants help with this chemical imbalance and gets you back on track. If you are to try an anti-depressant, try Effexor. Paxil and Prozac have very harsh side effects. One of my friends is on Effexor and has really changed alot from how she once was. I would talk to my Psychiatrist first to find out exactly how long you need to be on the medication and discuss dosage. The average depressed person should be monitored regularly by their doctor to make sure your medicine is working for you.
                                                                                      I have been on Effexor for 4 years but i also have generalised anxiety disorder. If i miss a few pills my brain turns to mush and I can't stop crying and I feel drunk and can't hear very well.
                                                                                      Stupid pills are so expensive it costs me like 80 bucks/month.
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