Ofcourse it's possible. Using a submitter like
GallerySubmitter.com isn't different than from submitting manually.
So if you can make 3 sales a week by doing manual submissions, then you can make 3 sales a week using an autosubmitter.
They keys to making sales are:
1. good content
2. clever designs
3. partner accounts
If you have all three, then there's no reason why you shouldn't make 3+ sales a *day*.