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OVERDOSAGE:
"Serious potential consequences of overdosage are respiratory depression, lethargy, coma, seizure, cardiac arrest and death. (See
WARNINGS.) Fatalities have been reported in post marketing in association with both intentional and unintentional overdose with
ULTRAM. In treating an overdose, primary attention should be given to maintaining adequate ventilation along with general support-ive
treatment. While naloxone will reverse some, but not all, symptoms caused by overdosage with ULTRAM, the risk of seizures is
also increased with naloxone administration. In animals convulsions following the administration of toxic doses of tramadol could be
suppressed with barbiturates or benzodiazepines but were increased with naloxone. Naloxone administration did not change the
lethality of an overdose in mice. Hemodialysis is not expected to be helpful in an overdose because it removes less than 7% of the
administered dose in a 4-hour dialysis period."
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