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1968 with the Hong Kong Flu outbreak. In 1957, the Asian flu pandemic resulted in about 70,000 deaths. The most deadly influenza pandemic outbreak was the 1918 Spanish flu pandemic, which caused illness in roughly 20 to 40 percent of the world's population and more than 50 million deaths worldwide. Between September 1918 and April 1919, approximately 675,000 deaths from the Spanish flu occurred in the United States alone.
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