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Originally Posted by wedouglas
It's because of the cardio involved in high repetitions. Heavy weight at high reps will do exactly the same, only problem is that you can't do high reps at high weights. That means that weight has less to do with it than reps.
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Also, come to think of it, there isn't much cardio work in low weight reps if you're in shape. I can curl 40 lbs for an hour without running out of breath or getting my heart rate up much. My arms will burn as I use up the last of the lactic acid though.