Definately Family Guy, though my opinion is probably biased because I never really got into the Simpsons.
I just prefer the humor of Family Guy, and you can't help but love how they work in some 80s appearance in every episode, whether it be the Kool-Aid man breaking through the wall out of nowhere, Prince Adam mounting a donkey and becoming He-Man, or a GI:JOE popping out of the bathroom stall....I absolutely LOVE those
