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Old 10-17-2017, 11:39 AM  
CPA-Rush
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There are several chromosomal abnormalities associated with the sex chromosomes: Turner Syndrome , Triple X Syndrome , XYY syndrome , and Klinefelter's Syndrome . Those with the first two are physiologically female, while those with the last two are physiologically male. I don't know if the ratio of those with these conditions that self-identify as transgender is higher than that of the normal population. It is probably difficult to determine because Turner Syndrome is very rare (it's thought that most fetuses with this condition are terminated as miscarraiges), or in the case of the other three are often never diagnosed because for many there are no visible symptoms.
Also remember that even for people that identify themselves as trans-gender, they are still genetically the same as the day they were born. Surgery can make cosmetic changes to their primary sexual characteristics (i.e. appearance of genitalia), and hormone therapy can change secondary sexual characteristics (hair, body fat proportions, breasts, voice, etc.), but genetically they are still the XY or XX that they were born with


https://ghr.nlm.nih.gov/condition/kl...syndrome#genes
https://ghr.nlm.nih.gov/condition/swyer-syndrome

WHO | Gender and Genetics
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