I loved living in Vegas. The weather is great (even in the summer IMO). Because of the low cost of living, you get a pretty high quality of life for an average amount of money. Lots of great restaurants, lots to do, lots of concerts, lots of 24 hour places, direct flights to pretty much anywhere.
Henderson is the popular area, but not the only one. I liked living in the south west, other people like Summerlin and Red Rock. Spend some time first and check out all the areas, it could come down to what is available on the market in your budget.
If I moved back I'd be tempted to do the Panorama Tower thing though...
