No problems with drivers on your audio equipment? Or did you not update that computer?
The music system is still on Yosemite. No real need to update it and there's too much I am scared of breaking on that machine.
The other two iMacs are on Sierra though, seems fine with everything I use which includes a Fujitsu ScanSnap, Dymo LabelWriter, Blackmagic Design H264 Pro Recorder and a 32TB Pegasus2 R8 Thunderbolt 2 Disk System, Fuji Xerox DocuPrint CM305DF and a Fuji Xerox Docuprint CM205FW
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