Seattle and Portland are both wonderful cities...similar to smaller versions of San Francisco in many respects.
Seattle is my hometown (although I consider myself to have grown up in Hawaii), and aside from the weather for much of the year, I love visiting there.
I was in Portland a week or so ago and absolutely had a great time. I would describe Portland as a very progressive arts-oriented city, with a small college town kind of vibe.
I didn't realize that so many GFYers whom I like live up that way - will have to hit some of you up before my next trip and maybe we can meet up.
ADG