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You seriously are asking questions that are vague so that in order to create any dollar value requires more detail but here is a range that may help
- Design: ($500 to $15000) depending on site depth and integration etc.
- CMS: again varies as content management systems can range from cheap to overpriced
- Payment integration: look around but getting a merchant account can be costly but without any details again you can be paying 700$ to 70000$
- Content: You speak of niches but there are good deals but without how much content and what kind (video/pictures - plugin's - shoot it yourself or purchase rights limited etc) from $0 to 70000$ depending on exclusivity or whether you simply want to sign up for an affiliate program and don't want your own content that is unique - not to mention hosting or even marketing - SEO work - blogs etc
I hope you get the point in that your question is not specific enough and also doesn't include other necessities
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