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We typically employ a strategy where as we optimize your setup based around the technologies you are employing. For MySQL based, we would probably recommend at least a 2 server setup, one running FreeBSD with optimization for web/php, and one as a dedicated Linux MySQL server. We can easily grow this solution into a clustered setup, whereas you'll have multiple web servers load balanced and using or cloud to serve your content, and a clustered MySQL environment to meet your individual requirements. It all depends on what your running. There are many variables to take into consideration =) Additionally, while it was mentioned that we "prefer" bsd, we will host and support any OS YOU prefer.
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