depends on how much time you have
italy without rome and venedig makes less sence, if you have more time you should also visit pompeji ant the vesuv vulcano in the south
Palermo is really worth checking out. I did Tuscany, Pisa, Florence, Rome, Naples, Palermo this spring. Palermo was the best in my opinion. Beautiful city, friendly people, and much less turists than the rest of Italy.
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