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Go to Duplex if you want to see nothing but tourists and swarms of Italians. Not to mention getting raped on beer. MishMash is ok, nothing special.
Mecca is ok if you want higher end euro trash and trendy house shit. Roxy is a good mix of tourists and locals, lots of drugs available. Zero is small but packed with expats and hot poon, drugs a plenty. Cross Club if you want drum and bass and a good freak show, bring your own drugs. The real party doesnt start in Prague till 5 am, then you can either head to Studio or Le Clan. Le Clan is more laid back and druggy oriented, you probably want Studio. All the strippers head there when they get off work. Its close to main train station, not hard to find, ask around.
In general, stay out of the center. Its nothing but tourists and expensive beer.
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