Hmm, these are what I can't live without:
Photoshop & Fireworks - Fireworks is easier and faster, Photoshop is prettier but slower
Sony Vegas - Video editing has never been easier than this
ITunes & Last.fm - All my tunage belongs to them
Flex & Flash CS3 - Nuff said
Cute FTP - Most streamlined FTP IMHO
Dreamweaver - Quick and simple site mods
Videocharge Pro - Ripping, splitting, watermarking, encoding video in several formats (H.264,WMV, XVID, Flash 8) and uploading while I sleep ;)