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Worse than some, not as bad as others. MDMA can fuck with your body's natural ability to produce serotonin. I've noticed that people who take it regularly seem to get a deep hallowed-eye look, and - after awhile - don't really seem to feel emotion unless they're rolling (think 6 pills a night, 2-3 nights a week for a few months). Seems to correct after awhile, but I've heard it can permanently fuck with your biochemistry if you take too much of it.
Not to mention, people cut the shit out of pills, so who knows what you're really getting... the days of the pure Dove are long gone.
I imagine anything in moderation's probably safe, though.
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-D.
ICQ: 202-96-31
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