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Closing off comments etc., is not a good idea. Most adult blogs will not get a lot of useful comments, but it's all free labor providing extra food for other visitors and the SE's.
Akismet has a good reputation, but commercial sites are supposed to pay for the service. I'm not aware of anyone being denied access for failing to pay if they should, but your site makes a call to their server each time someone attempts to post a comment and free users are handled more slowly than those who do pay.
I have comments open and I do not moderate. Still it's unusual if even one spam a month makes it onto my sites. I have pinging and trackbacks disabled on adult sites (since our "community" only rarely makes legitimate use of these features). Otherwise I use a combination of Bad Behavior and Spam Karma, since they cover different spam characteristics.
It is particularly important to have Spam Karma recognize posts older than 10-15 days as "old", since the vast majority of automated spam hits older posts.
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