Originally Posted by edgeprod

Very *few* issues, at least.

It was a pain to get running and tweak, but now that it's up, it's cooking along nicely. I use Autoblogger Pro to "seed" it with blogs so that people are encouraged to make their own (i.e., it doesn't look dead). They crank up to a few thousand visitors within the first month, which is nice .. and then grow nicely after that.

Nice selection of themes (most WP themes work with MUWP as well), comes with the source code so you can modify it, etc.

Aside from the people who've never even run it groaning about it hogging resources that you'll have to listen to over and over ... MU WordPress gets my recommendation, too.