Dreamsubmitter is my program of choice with Chameleon being a close second.
DS has the best support I have ever come across (I wish those guys worked for the affiliate programs I use!) and the people there are only to happy to talk you through the program one-on-one, make tweaks if you find a glitch or even if you have an idea on how to improve the program. Now it takes me longer building the gallery than submitting!
I find that there's much less room for error in DS and it can be used for other kinds of submitting, not just sticking to the usual gallery submits.
Picposts, linkdumps, search engines etc... DS is a little more complex than most of the submitters I've tried but with the support being fantastic and the tutorial videos, it really doesn't take long to get used to the program, it only takes minutes to get set up for submitting.
They do have a great database too, updated weekly, seems to be much more productive than the Chameleon one though i think chams is slightly bigger. The progam has helped me go from zero sales a week to mega sales a week, infact I bought a laptop last week from porn money
My favourite feature is that you can leave some great notes in DS, you can also group the tgps - 1 submit per day, 3 submits , 100 submits per day, partner only per day, etc etc..
if a newbie like me can make use of it and make money from it, any porn pro out there would adore the program!