If you are on a Cpanel server I would recommend utilizing the Boxtrapper feature.
Short of that you might use Spamarrest(I believe that is teh name) similar to the Cpanel boxtrapper, but ran by a third party. I have never used them because I didn't want to be reliant on a third party for my mail. Then Cpanel released their Boxtrapper and it has been a real treat and totally effective.
I used regular filters before but they just got too slow and unreliable.
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