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Yes.... on my $5k car stereo I DO hear a difference in the depth of the bass between the CD version, and the alt-preset-extreme VBR MP3 of the same song, but out of convenience I only carry around my MP3 CDs in the car. I do agree with Infecto that there IS a difference in sound quality on high end systems, but also agree with everyone else that lossy is the way of the present and future. There will always be SACD type situations for the high end guys.
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