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Old 11-10-2005, 06:46 PM  
NoCarrier
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Join Date: Mar 2002
Location: Montreal
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Bird flu causes fatal immune storm, study finds. This will be "Spanish Flu" Redux.

This is what I didn't want to find out.. H5N1 causes a cytokine storm.

The more healthy you are, the more your immunity system will kill you. A cytokine storm is a cascading hyper-reaction of the immune system so severe that attacking the flu virus actually kills the host.

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Bird flu causes fatal immune storm, study finds

http://today.reuters.com/news/NewsAr...mber=1&summit=

CHEMICAL STORM

The H5N1 viruses brought in a storm of cytokines -- the immune system's inflammatory chemicals -- including IP-10, interferon beta, RANTES and interleukin-6. The H1N1 virus caused a much smaller effect.

And the later, Vietnamese strains caused a bigger cascade than the 1997 H5N1 strain.

This could be because of continued mutations, the researchers said. "The H5N1 viruses have continued to reassort, acquiring different internal genes from other influenza viruses of avian origin," the researchers wrote.

The study, published on the Internet at http://respiratory-research.com/, may explain the severe respiratory distress suffered by H5N1 patients, who often say they struggle to breathe.

Michael Osterholm, an infectious disease expert at the University of Minnesota who has been advising the U.S. government on the risks of a flu pandemic, said the study supports predictions that any possible H5N1 pandemic would be especially severe.

It means being young and healthy could actually work against people who become infected.

"Anyone could experience this very severe, life-threatening illness," Osterholm said in a telephone interview.

"This is looking more and more like an H1N1 1918."

The worst recorded influenza epidemic was in 1918, when an H1N1 strain swept the globe in a few months, killing anywhere between 20 million and 100 million people, depending on the estimate. In comparison, a pandemic in 1957 killed 2 million and one caused by an H3N2 virus in 1968 killed 1 million.

"In 1918, even among the very young and the very old, there was a ten-fold increase in deaths," Osterholm said. "There was a 1,000-fold increase in young adults."

Fauci said researchers are now testing various drugs that may affect the immune system to see if they would help patients better survive H5N1.
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Last edited by NoCarrier; 11-10-2005 at 06:48 PM..
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