Cloudmark is the best. It uses P@P to always ad new spam from other people mailboxes. Also is used by paypal to stop phishing. Best of the bunch in my opinion.
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Cloudmark is the leading anti-spam and anti-phishing provider for organizations ranging from small businesses to Global 2000. Today, Cloudmark protects millions of mailboxes in over 160 countries and thousands of enterprises worldwide.
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http://www.cloudmark.com/