Originally Posted by Equinox

Well, there is tons of optimizing methods for adsense. I've learned that it comes even down to the the whole layout of your site, not just the adsense placement. I managed to improve my CTR tremendously, allowing me to cruise at 150-300 bucks a day from adsense alone.

Quick tip:

the slim one line banners with 4 or 5 links are killer!