Originally Posted by Elli

A few things:

Pro is far more stable than Home. Home is notoriously wonky.
Make sure you have your paging file set on a drive that isn't being used a lot and won't interfere with program function. Like the last drive in your list.
Make sure you have enough RAM. Try a proggie like CacheManXP (it's free) to show you how much ram you're actually using and to recover ram from closed programs.
Try defragmenting everything.