The best thing I can tell you is to remember that the Turks and Greeks don't get along
I lived in Southern Turkey for awhile (in the 80's) and visited athens several times... once I got into a conversation with a Greek cab driver and mistakenly told him I was living in Turkey... To make a long story short he got pissed and dropped me off at the wrong place
Driving a car is a nightmare... There are basically no traffic rules... It's like anarchy
Don't say "peach" to a Turk. It's an insult
Don't show the heel of your shoes in Turkey. It's an insult
Basically, you'll pretty much like all the normal tourist stuff in those big cities. Check out the blue mosque in Istanbul and definately the Acropolis in Athens Personally, I prefered the rural areas and had the most fun just ending up in little villages off the beaten path etc.
Maybe plan on buying some meerschaum pipes when you're in Istanbul.
The town of Ephesus
http://www.ephesusguide.com/ near Izmir was definately a highlight back then...
Have fun! I'd like to see the those countries today.. they've probably changed a bit since I was there 20 years ago