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The patch will introduce estrogen and progesterone into his body...
The estrogen could make him moody (depressed/girly), give him erectile issues and depending on the amount introduced and his sensitivity, induce gynocemastia (tits).
The progesterone is similar to estrogen (more progesterone = more estrogen) and could also induce gynocemastia... if his blood levels are high enough he could start to lactate a little. This could also cause erectile disfunction and a loss of libido (due to the estrogen increase).
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