it sounds like a script mapping problem or the directory is not set up with execute permissions. If he has administrative privs on the box he should make sure it is mapped correctly and the directory is set with execute privs. If he doesn't then he should ask his sys admin to look at it.
How do I configure Microsoft IIS 4.0/IIS 5.0 to support ActivePerl?
http://aspn.activestate.com//ASPN/Re..._Microsoft_IIS
cheers