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The bottom line for me has always been VPC (Value per Click).
Log your own outbound clicks, and look at how much money you make for sending those raw clicks.
Whomever you make the most money with is who should get the bulk of your traffic.
Test out lots of different Affiliate Programs that cater to your particular Niche or type of traffic. Once you have a few that you are comfortable doing business with and make you the most money start working on other sources of traffic.
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