RedShoe

I'm experiencing something similar.
I can't set my homepage the "make homepage" button in the Internet Settings is greyed out. I have to manually alter the "regedit" to change the homepage.

I've tried everything short of reinstalling the OS. Nothing seems to fix it.

When it happened, the script/virus changed my homepage to a yahoo look-a-like, except half of it was in a foreign language, and the links looked all fucked up, and so a fake "language pack" window would pop-up. I assume that was the more serious virus, or a dialer.

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