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Originally Posted by demented
Normally just restarting the computer works, unless the program that's using it is starting up when the computer starts up. I would suggest finding out what program is using it, and disabling it from starting up, then restart, and try to delete the file.
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I've tried all that, but there's no program that I can find that's using it...booting into safe mode should have gotten rid of any program that could have been using it, unless I suppose it's a critical system file...