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psilocybin mushrooms contain a poison (psilocin) that creates the trip effect. While poisons are usually not things to mess around with this and many plant poisons will cause you to vomit far before you would die or have other serious effects from it. One negative effect (though more comical and embarrasing than troubling) is that they can give you gas both belching and farting so try not to have mexican food because it only adds to the gas. also nausea may take hold right before the trip really starts (for me its how to know if it will work at all) while i've never vomited i'm sure its possible, bring weed to smoke 15 minutes after you eat them.
Aside from weed to control nausea weed also helps with other uncomfortable aspects of shrooming. For instance theres another active chemical in the stems taht accounts for the body high and anxiety before the trip starts. Weed perfectly calms the anxiety and puts you in a good mood. I have always had lots of weed with shrooms and my trips are always pleasent
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