We use AdultWebWare on our main site
http://www.virtualmedusa.com
Thanks to the great support we managed to get our project online quite soon.
Right now we have 11 different theme channels and work with about 40 Gigabyte of data files. All managed by AWW.
AWW handles this with ease and makes updating now a really quick job.
I have worked with other system like MAS for example, but I strongly prefer the structure and quick support of AWW.