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I assume you are asking about Zend Performance Suite (the one with the cache license)
Depends on your setup & sites, because you cannot cache some stuff.
For example, if your php script needs to displays time by seconds or you'll need current copy of mysql data you cannot cache those (or just those parts in scripts).
If you do, they will continue show same data for 360 seconds (you can change that). When timed out, they'll update those data again.
Also you should not cache POST & GET operations.
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