I use Mozilla Thunderbird (also use Mozilla FireFox as my browser when I'm not testing IE compatibility).
I like Firefox. I really liked Outlook, but the thing has more security holes than I cared to put up with. Thunderbird has some reasonably configurable filters and sorting tools, and I have it set-up to prompt me before it downloads any attachment (and I just cancel so no attachments get downloaded).
I'd recommend it if you don't need any of the extra features that Outlook has.
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