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Depends. What is the read to write ratio for each site? If you're doing relatively few writes you're probably better off with 1 master and 3 slaves. If you're doing lots of writes, go with 2 masters and 2 slaves.
Also, don't overlook the value of http accelerators (reverse caches) on heavily dynamic sites.
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"Every normal man must be tempted, at times, to spit on his hands, hoist the black flag, and begin slitting throats."
--H.L. Mencken
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