I have this Denon receiver. I love it, and also compared it side by side with the comparable Marantz. I went with the Denon because of it's features and smoother sound.
I have it hooked up to Boston Acoustics VRC center speaker, 4 Boston Acoustics VR-950 towers (2 in front and 2 in back), Mirage side speakers and a powered 15" Mission sub woofer.
The BA speakers never "speaker fatigue" me. I had some Klipsch, but I returned them due to speaker fatigue.
Here's a pic of my theater room. You can't see it, but the second row is raised seating
