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Contact lenses are easy. Just always wash your hands very well whenever you handle them. Acuvue 2's by Johnson & Johnson are the ones I wear and you can't even feel anything in your eye.
I take mine out once each week and disinfect them. Most are recommended for 2 weeks useage, but if you disinfect them they'll stay comfortable for a week or two more typically.
My ex-wife got a serious eye infection with hers from handling them after doing her makeup and not washing her hands first and keeping them in past the recommended period. She was hospitalized for a week with psuedomoneous and got a permenant corneal scar from it, which left her with slightly blurred vision in that eye. So you do need to be careful. Bacteria can get on them and do serious damage if you are not careful.
A lot of people say take them out every night, but in my opinion and I've been wearing these for over 20 years, the more you handle them the greater the likelihood you'll get an infection accidently. I've found, at least for me, the once a week rinse works sufficiently.
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