Seems not by default for new domains the user is visiting:
https://developer.chrome.com/blog/autoplay
Quote:
Chrome's autoplay policies are simple:
- Muted autoplay is always allowed.
- Autoplay with sound is allowed if:
- The user has interacted with the domain (click, tap, etc.).
- On desktop, the user's Media Engagement Index threshold has been crossed, meaning the user has previously played video with sound.
- The user has added the site to their home screen on mobile or installed the PWA on desktop.
- Top frames can delegate autoplay permission to their iframes to allow autoplay with sound.
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