You can run several twitter accounts at once, however this would require proxies and a bot. From my experience if you start follow/unfollow method slowly you can reach about 400 follows everyday on the month three. Start with 10/day, increase by 10 every day, and eventually you will reach your goal.
As for actual followers, this depends on your niche and what you post. Look for the big accounts in your niche and find out the things the particular audience craves for.
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