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Well the CRISPR/Cas9 cuts DNA as if it were scissors so theres your DNA damage.... So its in its early stages and cutting a bit off mark in a sloppy way. They'll improve it in time.
"However, during these experiments CRISPR caused deletions or rearrangements more than 100 DNA letters long in around a fifth of cells. These mutations happened in some cases several thousand DNA bases away from the target site."
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