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IMO you should just work with ad networks. I run tubes with millions of users a month; I'm happy with the ad networks I'm using (exoclick, adxpansion, Adultforce).
Juicyads does prepay deals but you need to be way bigger before they'll talk to you.
You can increase your banner cpm by using standard sizes (300x250 desktop, 300x100 mobile), visible placements, and multiple ad networks (use a diff network for each ad spot).
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